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1

Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies

Rob C. Roovers, Toon Laeremans, Lieven Huang, Severine De Taeye, Arie J. Verkleij, Hilde Revets, Hans J. de Haard, Paul M. P. van Bergen en Henegouwen

Journal:

Cancer Immunology, Immunotherapy

Year:

2007

Language:

english

File:

PDF, 542 KB

english, 2007

2

Targeting tumors with nanobodies for cancer imaging and therapy

Oliveira, Sabrina, Heukers, Raimond, Sornkom, Jirawas, Kok, Robbert J., van Bergen en Henegouwen, Paul M.P.

Journal:

Journal of Controlled Release

Year:

2013

Language:

english

File:

PDF, 1.31 MB

english, 2013

3

The epidermal growth factor.

Johannes Boonstra, Philip Rijken, Bruno Humbel, Fons Cremers, Arie Verkleij, Paul van Bergen en Henegouwen

Journal:

Cell Biology International

Year:

1995

File:

PDF, 1.06 MB

1995

4

MAGE-A antigens as targets for cancer immunotherapy

Schooten, Erik, Di Maggio, Alessia, van Bergen en Henegouwen, Paul M.P., Kijanka, Marta M.

Journal:

Cancer Treatment Reviews

Year:

2018

Language:

english

File:

PDF, 950 KB

english, 2018

5

Imaging of Tumor Spheroids, Dual-Isotope SPECT, and Autoradiographic Analysis to Assess the Tumor Uptake and Distribution of Different Nanobodies

Beltrán Hernández, Irati, Rompen, Rene, Rossin, Raffaella, Xenaki, Katerina T., Katrukha, Eugene A., Nicolay, Klaas, van Bergen en Henegouwen, Paul, Grüll, Holger, Oliveira, Sabrina

Journal:

Molecular Imaging and Biology

Year:

2019

File:

PDF, 1.67 MB

2019

6

Homo-FRET Imaging as a Tool to Quantify Protein and Lipid Clustering

Dr. Arjen N. Bader, Dr. Sandra Hoetzl, Dr. Erik G. Hofman, Jarno Voortman, Dr. Paul M. P. van Bergen en Henegouwen, Prof. Dr. Gerrit van Meer, Prof. Dr. Hans C. Gerritsen

Journal:

Year:

2011

Language:

english

File:

PDF, 974 KB

english, 2011

7

Inside Cover: Homo-FRET Imaging as a Tool to Quantify Protein and Lipid Clustering (ChemPhysChem 3/2011)

Dr. Arjen N. Bader, Dr. Sandra Hoetzl, Dr. Erik G. Hofman, Jarno Voortman, Dr. Paul M. P. van Bergen en Henegouwen, Prof. Dr. Gerrit van Meer, Prof. Dr. Hans C. Gerritsen

Journal:

Year:

2011

File:

PDF, 645 KB

2011

8

A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth

Rob C. Roovers, Maria J.W.D. Vosjan, Toon Laeremans, Rachid el Khoulati, Renée C.G. de Bruin, Kathryn M. Ferguson, Arie J. Verkleij, Guus A.M.S. van Dongen, Paul M.P. van Bergen en Henegouwen

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 1.12 MB

english, 2011

9

An improved method for producing gold particles of particular sizes

Paul Van Bergen En Henegouwen, Jan Leunissen

Journal:

Ultramicroscopy

Year:

1984

Language:

english

File:

PDF, 193 KB

english, 1984

10

Localization of the 84,000-Dalton heat shock protein in N2A neuroblastoma cells

Paul van Bergen en Henegouwen, Guy Berbers, Jan Vinjé, Karel Schotanus

Journal:

Ultramicroscopy

Year:

1986

Language:

english

File:

PDF, 91 KB

english, 1986

11

Application of colloidal gold particles in visualization of the cytoskeleton in ultrathin cryosections

Paul van Bergen en Henegouwen, Jan Leunissen

Journal:

Ultramicroscopy

Year:

1986

Language:

english

File:

PDF, 175 KB

english, 1986

12

Eps15: a multifunctional adaptor protein regulating intracellular trafficking

Paul MP van Bergen en Henegouwen

Journal:

Cell Communication and Signaling

Year:

2009

Language:

english

File:

PDF, 359 KB

english, 2009

13

Facile labelling of an anti-epidermal growth factor receptor Nanobody with68Ga via a novel bifunctional desferal chelate for immuno-PET

Maria J. W. D. Vosjan, Lars R. Perk, Rob C. Roovers, Gerard W. M. Visser, Marijke Stigter-van Walsum, Paul M. P. van Bergen en Henegouwen, Guus A. M. S. van Dongen

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2011

Language:

english

File:

PDF, 388 KB

english, 2011

14

The blood–brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells

Abedelnasser Abulrob, Hein Sprong, Paul Van Bergen En Henegouwen, Danica Stanimirovic

Journal:

Journal of Neurochemistry

Year:

2005

Language:

english

File:

PDF, 548 KB

english, 2005

15

Sequence-specific1H,13C and15N assignment of the EH1 domain of mouse Eps15

Brian Whitehead, Marco Tessari, Henri H. Versteeg, Sanne van Delft, Paul M. P. van Bergen en Henegouwen, Geerten W. Vuister

Journal:

Journal of Biomolecular NMR

Year:

1998

Language:

english

File:

PDF, 35 KB

english, 1998

16

Letter to the Editor: Sequence-specific 1H, 13C and 15N assignment and secondary structure of the apo EH2 domain of mouse Eps15

Alfonso Carotenuto, Marco Tessari, Brian Whitehead, Jan M.A. Aelen, Paul M.P. van Bergen en Henegouwen, Geerten W. Vuister

Journal:

Journal of Biomolecular NMR

Year:

1999

Language:

english

File:

PDF, 36 KB

english, 1999

17

EGF stimulation of c-fos expression is inhibited by dihydrocytochalasin B and not by colchicine

Paul van Bergen Henegouwen, Mark Tuyl, Arie Verkleij, Johannes Boonstra

Journal:

Cell Differentiation and Development

Year:

1989

Language:

english

File:

PDF, 91 KB

english, 1989

18

Downregulation of EGFR by a novel multivalent nanobody-liposome platform

Sabrina Oliveira, Raymond M. Schiffelers, Joris van der Veeken, Roy van der Meel, Ranitha Vongpromek, Paul M.P. van Bergen en Henegouwen, Gert Storm, Rob C. Roovers

Journal:

Journal of Controlled Release

Year:

2010

Language:

english

File:

PDF, 1012 KB

english, 2010

19

Nanobody — Shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting

Marina Talelli, Cristianne J.F. Rijcken, Sabrina Oliveira, Roy van der Meel, Paul M.P. van Bergen en Henegouwen, Twan Lammers, Cornelus F. van Nostrum, Gert Storm, Wim E. Hennink

Journal:

Journal of Controlled Release

Year:

2011

Language:

english

File:

PDF, 739 KB

english, 2011

20

Reprint of "Nanobody — Shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting"

Marina Talelli, Cristianne J.F. Rijcken, Sabrina Oliveira, Roy van der Meel, Paul M.P. van Bergen en Henegouwen, Twan Lammers, Cornelus F. van Nostrum, Gert Storm, Wim E. Hennink

Journal:

Journal of Controlled Release

Year:

2011

Language:

english

File:

PDF, 775 KB

english, 2011

21

Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment

Roy van der Meel, Sabrina Oliveira, Isil Altintas, Rob Haselberg, Joris van der Veeken, Rob C. Roovers, Paul M.P. van Bergen en Henegouwen, Gert Storm, Wim E. Hennink, Raymond M. Schiffelers, Robbert

Journal:

Journal of Controlled Release

Year:

2012

Language:

english

File:

PDF, 820 KB

english, 2012

22

Imaging of protein cluster sizes by means of confocal time-gated fluorescence anisotropy microscopy

Bader, Arjen N., Hofman, Erik G., van Bergen en Henegouwen, Paul M. P., Gerritsen, Hans C.

Journal:

Year:

2007

Language:

english

File:

PDF, 469 KB

english, 2007

23

The Actin Binding Domain of the Epidermal Growth Factor Receptor Is Required for EGF-Stimulated Tissue Invasion

Marcel A.G. van der Heyden, Paul M.P. Van Bergen en Henegouwen, Nancy de Ruiter, Marina A.M. Verdaasdonk, Jan G. van den Tweel, Gert Rijksen, Johannes Boonstra, Piet Joling

Journal:

Experimental Cell Research

Year:

1997

Language:

english

File:

PDF, 326 KB

english, 1997

24

Cholesterol and phosphoinositides increase affinity of the epidermal growth factor receptor

Jan C. den Hartigh, Paul M.P. van Bergen en Henegouwen, Johannes Boonstra, Arie J. Verkleij

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1993

Language:

english

File:

PDF, 879 KB

english, 1993

25

Heat shock gene expression and cytoskeletal alterations in mouse neuroblastoma cells

Paul M.P. van Bergen en Henegouwen, Wilbert A.M. Linnemans

Journal:

Experimental Cell Research

Year:

1987

Language:

english

File:

PDF, 2.29 MB

english, 1987

26

Heat shock-induced redistribution of a 160-kDa nuclear matrix protein

Arjan de Graaf, Alexandra M.L. Meijne, A.Jos B.M. van Renswoude, Bruno M. Humbel, Paul M.P. van Bergen en Henegouwen, Luitzen de Jong, Roel van Driel, Arie J. Verkleij

Journal:

Experimental Cell Research

Year:

1992

Language:

english

File:

PDF, 14.15 MB

english, 1992

27

The epidermal growth factor receptor is associated with actin filaments

Paul M.P. van Bergen en Henegouwen, Jan C. den Hartigh, Petra Romeyn, Arie J. Verkleij, Johannes Boonstra

Journal:

Experimental Cell Research

Year:

1992

Language:

english

File:

PDF, 5.88 MB

english, 1992

28

Epidermal growth factor induces serine phosphorylation of actin

Sanne van Delft, Arie J. Verkleij, Johannes Boonstra, Paul M.P. van Bergen en Henegouwen

Journal:

Year:

1995

Language:

english

File:

PDF, 441 KB

english, 1995

29

A NPxY-independent β5 integrin activation signal regulates phagocytosis of apoptotic cells

Sukhwinder Singh, Veera D’mello, Paul van Bergen en Henegouwen, Raymond B. Birge

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 583 KB

english, 2007

30

Integrated fluorescence and transmission electron microscopy

Alexandra V. Agronskaia, Jack A. Valentijn, Linda F. van Driel, Chris T.W.M. Schneijdenberg, Bruno M. Humbel, Paul M.P. van Bergen en Henegouwen, Arie J. Verkleij, Abraham J. Koster, Hans C. Gerritsen

Journal:

Journal of Structural Biology

Year:

2008

Language:

english

File:

PDF, 522 KB

english, 2008

31

Morphological and biochemical evidence for partial nuclear localization of annexin 1 in endothelial cells

Patrick Raynal, Paul M.P. van Bergen en Henegouwen, Francoise Hullin, Jeannie M.F. Ragab-Thomas, Josette Fauvel, Arie Verkleij, Hugues Chap

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 5.63 MB

english, 1992

32

Identification of an intracellular domain of the EGF receptor required for high-affinity binding of EGF

Marcel A.G Van der Heyden, Mirjam Nievers, Arie J Verkleij, Johannes Boonstra, Paul M.P Van Bergen en Henegouwen

Journal:

Year:

1997

Language:

english

File:

PDF, 488 KB

english, 1997

33

Cyclooxygenase-dependent signalling: molecular events and consequences

Henri H Versteeg, Paul M.P van Bergen en Henegouwen, Sander J.H van Deventer, Maikel P Peppelenbosch

Journal:

Year:

1999

Language:

english

File:

PDF, 114 KB

english, 1999

34

Epidermal growth factor-induced activation and translocation of c-Src to the cytoskeleton depends on the actin binding domain of the EGF-receptor

Marcel A.G van der Heyden, Paschal A Oude Weernink, Brigitte A van Oirschot, Paul M.P van Bergen en Henegouwen, Johannes Boonstra, Gert Rijksen

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1997

Language:

english

File:

PDF, 364 KB

english, 1997

35

Nanobody-albumin nanoparticles (NANAPs) for the delivery of a multikinase inhibitor 17864 to EGFR overexpressing tumor cells

Altintas, Isil, Heukers, Raimond, van der Meel, Roy, Lacombe, Marie, Amidi, Maryam, van Bergen en Henegouwen, Paul M.P., Hennink, Wim E., Schiffelers, Raymond M., Kok, Robbert J.

Journal:

Journal of Controlled Release

Year:

2013

Language:

english

File:

PDF, 1.38 MB

english, 2013

36

Membrane vesicles of A431 cells contain one class of epidermal growth factor binding sites

Jos A.M. Berkers, Paul M.P. van Bergen en Henegouwen, Arie J. Verkleij, Johannes Boonstra

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1990

Language:

english

File:

PDF, 1.99 MB

english, 1990

37

The isolated neonatal rat-cardiomyocyte used in an in vitro model for ‘ischemia’. II. Induction of the 68 kDa heat shock protein

Mark J.M. Tuijl, Paul M.P. van Bergen en Henegouwen, Roeland van Wijk, Arie J. Verkleij

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1991

Language:

english

File:

PDF, 630 KB

english, 1991

38

Homo-FRET Imaging Enables Quantification of Protein Cluster Sizes with Subcellular Resolution

Bader, Arjen N., Hofman, Erik G., Voortman, Jarno, van Bergen en Henegouwen, Paul M.P., Gerritsen, Hans C.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 881 KB

english, 2009

39

Homo-FRET Imaging as a Tool to Quantify Protein and Lipid Clustering

Gerritsen, Hans, Bader, Arjen, Hofman, Erik, Voortman, Jarno, van Bergen, Paul, Henegouwen, en, van Meer, Gerrit

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 49 KB

english, 2011

40

Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

Zaiss, Dietmar M.W., van Loosdregt, Jorg, Gorlani, Andrea, Bekker, Cornelis P.J., Gröne, Andrea, Sibilia, Maria, van Bergen en Henegouwen, Paul M.P., Roovers, Rob C., Coffer, Paul J., Sijts, Alice J.A

Journal:

Year:

2013

Language:

english

File:

PDF, 875 KB

english, 2013

41

Inhibition of Tumor Growth by Targeted Anti-EGFR/IGF-1R Nanobullets Depends on Efficient Blocking of Cell Survival Pathways

van der Meel, Roy, Oliveira, Sabrina, Altintas, Isil, Heukers, Raimond, Pieters, Ebel H. E., van Bergen en Henegouwen, Paul M. P., Storm, Gert, Hennink, Wim E., Kok, Robbert J., Schiffelers, Raymond M

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 4.09 MB

english, 2013

42

Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains

Schmitz, Karl R., Bagchi, Atrish, Roovers, Rob C., van Bergen en Henegouwen, Paul M.P., Ferguson, Kathryn M.

Journal:

Year:

2013

Language:

english

File:

PDF, 2.07 MB

english, 2013

43

Single Quantum Dot Tracking Coupled to a Three-State HMM Provides New Mechanistic Insight Into erbB1 Homodimerization

Low-Nam, Shalini T., Lidke, Keith A., Cutler, Patrick J., Roovers, Rob C., van Bergen, Paul M.P., Henegouwen, en, Wilson, Bridget S., Lidke, Diane S.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 35 KB

english, 2011

44

Determination of Single Molecule erbB1 Homodimer Lifetimes Using Single Quantum Dot Tracking and a Diffusive Hidden Markov Model

Low-Nam, Shalini T., Lidke, Keith A., Cutler, Patrick J., Roovers, Rob C., van Bergen en Henegouwen, Paul M.P., Wilson, Bridget S., Lidke, Diane S.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 123 KB

english, 2010

45

Meeting announcements

Low-Nam, Shalini, Lidke, Keith, Roovers, Rob, van Bergen en Henegouwen, Paul, Wilson, Bridget, Lidke, Diane

Journal:

Reproductive Toxicology

Year:

1987

Language:

english

File:

PDF, 93 KB

english, 1987

46

Multi-color Single Quantum Dot Tracking To Characterize Membrane Receptor Interactions On Living Cells

Low-Nam, Shalini, Lidke, Keith, Roovers, Rob, van Bergen en Henegouwen, Paul, Wilson, Bridget, Lidke, Diane

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 40 KB

english, 2009

47

Correction

Low-Nam, Shalini, Lidke, Keith, Roovers, Rob, van Bergen en Henegouwen, Paul, Wilson, Bridget, Lidke, Diane

Journal:

Journal of the American Academy of Dermatology

Year:

1989

Language:

english

File:

PDF, 51 KB

english, 1989

48

Dissociation of NGF Induced Signal Transduction from Neurite Elongation by Expression of a Mutant Adaptor Protein v-Crk in PC12 Cells

Teng, Kenneth K., Courtney, Jody C., Henegouwen, Paul van Bergen en, Birge, Raymond B., Hempstead, Barbara L.

Journal:

Molecular and Cellular Neuroscience

Year:

1996

Language:

english

File:

PDF, 415 KB

english, 1996

49

Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4

Hagemeijer, Marne C., Monastyrska, Iryna, Griffith, Janice, van der Sluijs, Peter, Voortman, Jarno, van Bergen en Henegouwen, Paul M., Vonk, Annelotte M., Rottier, Peter J.M., Reggiori, Fulvio, de Haa

Journal:

Year:

2014

Language:

english

File:

PDF, 8.14 MB

english, 2014

50

Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin

Sanne van Delft, Christopher Schumacher, Willem Hage, Arie J. Verkleij and Paul M. P. van Bergen en Henegouwen

Journal:

The Journal of Cell Biology

Year:

1997

Language:

english

File:

PDF, 4.31 MB

english, 1997